CD20 / MS4A1 (B-Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone 93-1B3 ]
|Application ||IHC, FC|
|Other Accession||931, 712553|
|Isotype||Mouse / IgG1, kappa|
|Other Names||B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD20 / MS4A1 (B-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein may be involved in the regulation of B-cell activation and proliferation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor|
|Tissue Location||Expressed on B-cells.|
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Provided below are standard protocols that you may find useful for product applications.
Recognizes a protein of 30-33kDa, which is identified as CD20 (Workshop V; Code CD20.4). It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. The protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as calcium channel involved in B cell activation and cell cycle progression.
Cobbold, S. Et al., In leucocyte typing III (ed. McMichael A.J. et al.), Oxford University Press, 1987
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