CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone 203.6]
|Application ||IF, FC|
|Other Accession||939, 355307|
|Isotype||Mouse / IgG3, kappa|
|Other Names||CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Found in most T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27 (Workshop VI; Code 6T-028). CD27 is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFB and SAPK/JNK and induces apoptosis.
Kishimoto T et al. (eds) Leukocyte Typing VI. P67-71, Garland Publishing, New York, 1997
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