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CD86 (Dendritic Cells Maturation Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone C86/1146 ]

  • WB -  CD86 (Dendritic Cells Maturation Marker) Antibody - Without BSA and Azide AH12683
    Western Blot Analysis of Daudi Cell Lysate using CD86 Monoclonal Antibody (C86/1146).
  • IHC -  CD86 (Dendritic Cells Maturation Marker) Antibody - Without BSA and Azide AH12683
    Formalin-fixed, paraffin-embedded human Melanoma stained with CD86 Monoclonal Antibody (C86/1146).
  • FC -  CD86 (Dendritic Cells Maturation Marker) Antibody - Without BSA and Azide AH12683
    Flow Cytometry of human PBMC's using CD86 Monoclonal Antibody (C86/1146).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42081
Other Accession 942, 171182
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names C86/1146
Calculated MW 70kDa
Additional Information
Gene ID 942
Other Names T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B7.2, FUN-1, CD86, CD86, CD28LG2
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD86 (Dendritic Cells Maturation Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD86
Synonyms CD28LG2
Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed by activated B-lymphocytes and monocytes
Research Areas
Citations (0)

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Recognizes a protein of 70kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease.

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$ 354.00
$ 484.00
Cat# AH12683
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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