|Application ||WB, IHC, IF, FC|
|Other Accession||9476, 512843|
|Isotype||Mouse / IgG, kappa|
|Other Names||Napsin-A, 3.4.23.-, Aspartyl protease 4, ASP4, Asp 4, Napsin-1, TA01/TA02, NAPSA, NAP1, NAPA|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Napsin A (Lung Adenocarcinoma Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in processing of pneumocyte surfactant precursors.|
|Tissue Location||Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes|
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Napsin is a pepsin-like aspartic proteinase connected with maturation of surfactant protein B.ĀThere are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.
Bishop, JA et. al. Hum Pathol 41: 20-25 | Ordonez, NG 2012 Adv Anat Pathol 19: 66-73 | Ye, J et. al. Appl Immunhistochem Mol Morphol 19: 313-31
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