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>   home   >   Products   >   Primary Antibodies   >   Immunology   >    CD47 / IAP (Integrin Associated Protein) Antibody - With BSA and Azide   

CD47 / IAP (Integrin Associated Protein) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone IAP/964 + B6H12.2 ]

     
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  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession Q08722
Other Accession 961, 446414
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG's
Clone Names IAP/964 + B6H12.2
Calculated MW ~50kDa
Additional Information
Gene ID 961
Other Names Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6, CD47, CD47, MER6
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD47 / IAP (Integrin Associated Protein) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD47
Synonyms MER6
Function Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain
Research Areas
Citations (0)

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Background

This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus.Ā CD47 may play a role in membrane transport and/or integrin dependent signal transduction.Ā

References

Edris B et. al. Proc Natl Acad Sci USA 109:6656-61 (2012). | Willingham SB et. al. Proc Natl Acad Sci USA 109:6662-7 (2012)

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$ 124.00
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Cat# AH12754-20
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