CD48 (Pan Leukocyte Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone 156-4H9 ]
|Application ||IF, FC|
|Other Accession||962, 243564|
|Isotype||Mouse / IgG1, kappa|
|Other Names||CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, SLAM family member 2, SLAMF2, Signaling lymphocytic activation molecule 2, TCT.1, CD48, CD48, BCM1, BLAST1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD48 (Pan Leukocyte Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
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Provided below are standard protocols that you may find useful for product applications.
Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.
Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, New York and London, 1997. | Yokoyama S et al. Expression of the Blast-1 activation/adhesion molecule and its identification as CD48. J Immunol 1991, 146(7):2192-2200. | Kwong YL et al. Flow cytometric measurement of glycosylphosphatidyl-inositol-linked surface proteins on blood cells of patients with paroxysmal nocturnal hemoglobinuria. Am J Clin Pathol 1994, 102(1):30-35 | Sandrin MS et al. CD48 is a low affinity ligand for human CD2.J Immunol 1993, 151(9):4606-4613. | Vaughan HA et al. The isolation of cDNA clones for CD48. Immunogenetics 1991, 33(2):113-117. | Vaughan HA et al. Hu Ly-M3--a human leukocyte antigen. Transplantation 1983, 36(4):446-450
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