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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    GITR / Tnfrsf18 (mouse) Antibody - With BSA and Azide   

GITR / Tnfrsf18 (mouse) Antibody - With BSA and Azide

Rat Monoclonal Antibody [Clone DTA-1 ]

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O35714
Other Accession 21936 (Mouse), 3180 (Mouse), 482508 (Mouse)
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype Rat / IgG2b, lambda
Clone Names DTA-1
Calculated MW 66-70kDa (Homodimer)
Additional Information
Gene ID 21936
Other Names Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, CD357, Tnfrsf18, Gitr
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions GITR / Tnfrsf18 (mouse) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tnfrsf18
Synonyms Gitr
Function Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).
Cellular Location Isoform A: Cell membrane; Single-pass type I membrane protein Isoform C: Cell membrane; Single-pass type I membrane protein
Tissue Location Preferentially expressed in activated T lymphocytes
Research Areas
Citations (0)

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GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ĀCD4+ĀTregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-ĪŗB activation, and abrogate the inhibitory function ofĀCD25+ĀCD4+ĀTregs. In vivoĀactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.


Stephens GL, et al. 2004. J. Immunol. 173:5008. | Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059

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$ 124.00
$ 324.00
$ 454.00
Cat# AH12852
(40 western blots)
Availability: 2-3 days
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