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Cytokeratin 5/8 Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM268 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, FC |
|---|---|
| Primary Accession | P13647 |
| Other Accession | 3852 (CK5), 3856 (CK8), 433845 (CK5), 533782, 708445 (CK8), P05787 (CK8) |
| Reactivity | Human, Mouse, Rat, Hamster, Pig, Cow, Sheep, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | SPM268 |
| Calculated MW | 58kDa (CK5); 52.5kDa (CK8) |
| Gene ID | 3852 |
|---|---|
| Other Names | Keratin, type II cytoskeletal 5, 58 kDa cytokeratin, Cytokeratin-5, CK-5, Keratin-5, K5, Type-II keratin Kb5, KRT5 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Cytokeratin 5/8 Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRT5 |
|---|---|
| Function | Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in corneal epithelium (at protein level) (PubMed:26758872). Expressed in keratinocytes (at protein level) (PubMed:20128788, PubMed:31302245). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
It reacts with keratin 5 (58kDa) and keratin 8 (52.5kDa). Simple epithelia express cytokeratin 8 in combination with 18. On the other hand, basal cells of stratified epithelia express cytokeratin 5 paired with 14. This antibody therefore, reacts with a wide range of epithelia and their carcinomas.
References
Vojtĕšek et al. Folia Biol. 37(3-4): 197-206 (1991). | Bartkova et al. Neoplasma 38(4), 439-46 (1991). | Bartek et al. J. of Pathology 164, 215-24 (1991). | Kovařik et al. J. Tumor Marker Oncol. 5, 219 (1990). |
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