|Application ||WB, IHC-P, IF, FC|
|Other Accession||3851 (CK4), 3852 (CK5), 3853 (CK6A), 3854 (CK6B), 286887 (CK6C), 3856 (CK8), 3858 (CK10), 3860 (CK13), 3875 (CK18) (Human), P04259 (CK6B), P13647 (CK5), P19013 (CK4), P48668 (CK6C)|
|Reactivity||Human, Mouse, Rat, Monkey, Pig, Goat, Cow, Guinea Pig|
|Isotype||Mouse / IgG1|
|Calculated MW||Multiple KDa|
|Other Names||Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Cytokeratin, Multi (Epithelial Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.|
|Tissue Location||Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, including 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 53kDa (CK13) and 45kDa (CK18). This is a broad-spectrum antibody, which has been reported to differentiate epithelial tumors from non-epithelial tumors. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
Bartek J et. al. J Pathol, 1991, 164(3):215-24. ,Kasper M. Histochemistry, 1991, 95(6):613-20
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