|Application ||WB, IHC, IF, FC|
|Other Accession||374454 (KRT77), 51350 (KRT76), 334989 (KRT77), 654392 (KRT76), Q01546 (KRT76)|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Chicken, Cow, Dog|
|Isotype||Mouse / IgG's|
|Other Names||Keratin, type II cytoskeletal 1b, Cytokeratin-1B, CK-1B, Keratin-77, K77, Type-II keratin Kb39, KRT77, KRT1B|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Cytokeratin, pan (Epithelial Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed exclusively in skin.|
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Provided below are standard protocols that you may find useful for product applications.
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
Tseng SCG et. al. Cell 1982; 30361. | Woodock-Mitchell J et. al. Journal of Cell Biology 1982;95:580-8
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