Actin, Muscle Specific (Muscle Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone HHF35 + MSA/953 ]
|Application ||IHC-P, IF, FC|
|Other Accession||58, 59, 70, 118127, 1288, 500483, P68032, P68133|
|Reactivity||Human, Rat, Rabbit|
|Isotype||Mouse / IgG1, kappa|
|Clone Names||HHF35 + MSA/953|
|Calculated MW||Multiple KDa|
|Other Names||Actin, aortic smooth muscle, Alpha-actin-2, Cell growth-inhibiting gene 46 protein, ACTA2, ACTSA, ACTVS|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Actin, Muscle Specific (Muscle Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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This antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Actin can be resolved on the basis of its isoelectric points into three distinctive components: alpha, beta, and gamma in order of increasing isoelectric point. Anti-muscle specific actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative.ĀIt stains tumors of smooth muscle (leiomyomas and leiomyosarcomas) as well as skeletal muscle (rhabdomyomas and rhabdomyosarcomas).
Barkalow, K. and Hartwig, J.H. 1995. Actin cytoskeleton. Setting the pace of cell movement. Curr. Biol. 5: 1000-1002
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