Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) Antibody
Mouse Monoclonal Antibody [Clone 34BE12 ]
|Application ||WB, IHC, IF, FC|
|Other Accession||51350, 654392|
|Reactivity||Human, Mouse, Rat|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Keratin, type II cytoskeletal 2 oral, Cytokeratin-2P, CK-2P, K2P, Keratin-76, K76, Type-II keratin Kb9, KRT76, KRT2B, KRT2P|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably contributes to terminal cornification.|
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This antibody recognizes CK1, CK5, CK10 and CK14. In normal epithelia, it stains stratified epithelia, myoepithelial cells and basal cells in the prostate gland and bronchi. This MAb shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules, or endometrial glands; there is no reactivity with cells derived from simple epithelia. Mesenchymal tumors, lymphomas, melanomas, neural tumors, and neuroendocrine tumors are negative with this antibody. It stains myoepithelial cells and has been shown to be useful in distinguishing prostate adenocarcinoma from benign prostate. This antibody has also been useful in separating benign from malignant intraductal breast proliferations.
Moinfar F et. al. Am J Surg Pathol 1999;23(9):1048-58 | Varma M et. al. Mod Pathol 1999;12(5):472-8 |
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