Cytokeratin, Acidic (Type I or LMW) (Epithelial Marker) Antibody
Mouse Monoclonal Antibody [Clone AE-1 ]
|Application ||WB, IHC-P, IF, FC|
|Other Accession||374454, 334989|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Chicken, Cow, Dog|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Keratin, type II cytoskeletal 1b, Cytokeratin-1B, CK-1B, Keratin-77, K77, Type-II keratin Kb39, KRT77, KRT1B|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Cytokeratin, Acidic (Type I or LMW) (Epithelial Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed exclusively in skin.|
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Provided below are standard protocols that you may find useful for product applications.
This MAb recognizes the 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19) keratins of the acidic (Type I or LMW) subfamily. Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50ā€™, 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.
Woodock-Mitchell J et. al. Journal of Cell Biology 1982;95:580-8. | Tseng SCG et. al. Cell 1982; 30361
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