|Application ||WB, IHC-P, IF, FC|
|Other Accession||171577 (Rat), 106481 (Rat)|
|Isotype||Mouse / IgG1|
|Other Names||Epithelial cell adhesion molecule, Ep-CAM, Epithelial glycoprotein 314, EGP314, Protein D5.7A, Tumor-associated calcium signal transducer 1, CD326, Epcam, Tacstd1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Ep-CAM / CD326 (Rat) (Epithelial Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity).|
|Cellular Location||Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction|
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Provided below are standard protocols that you may find useful for product applications.
Epitopes of Epcam/1158 and Epcam/1159 monoclonal antibodies are different. EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas.
Litvinov SV et. al. J Cell Biol, 1994, 125:437-46. 2. Tsubura A et. al. J Cut Pathol, 1992, 19:73-9
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