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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Luteinizing Hormone / Choriogonadotropin Receptor (LHCGR) Antibody   

Anti-Luteinizing Hormone / Choriogonadotropin Receptor (LHCGR) Antibody

Mouse Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, FC
Primary Accession P22888
Other Accession 468490
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names LHCGR/1416
Calculated MW 78643 Da
Additional Information
Gene ID 3973
Other Names Gonadotropin receptor; GTHR-II; HHG; LCGR; LGR2; LH-R; LH/CG-R; LH/CGR; LHCGR; LHR; LHRHR; LSH-R; Luteinizing hormone receptor; Luteinizing hormone/choriogonadotropin receptor; Lutropin choriogonadotropic receptor; Lutropin-choriogonadotropic hormone receptor; ULG5
Application Note Flow Cytometry (0.5-1ug/million cells); ,Immunofluorescence (1-2ug/ml); ,Western Blotting (0.5-1ug/ml); ,Optimal dilution for a specific application should be determined.
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
PrecautionsAnti-Luteinizing Hormone / Choriogonadotropin Receptor (LHCGR) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LHCGR
Synonyms LCGR, LGR2, LHRHR
Function Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Gonadal and thyroid cells.
Research Areas
Citations (0)

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Background

Recognizes a protein of 78-85kDa, which is identified as Luteinizing hormone / choriogonadotropin receptor. Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

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$ 199.00
$ 429.00
Cat# AH13365-20
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