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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Spectrin beta III (SPTBN2) Antibody   

Anti-Spectrin beta III (SPTBN2) Antibody

Mouse Monoclonal Antibody

     
  • IHC-P - Anti-Spectrin beta III (SPTBN2) Antibody AH13518-20
    Formalin-fixed, paraffin-embedded Human Pancreas stained with Spectrin beta III Monoclonal Antibody (SPTBN2/1247).
  • IHC-P - Anti-Spectrin beta III (SPTBN2) Antibody AH13518-20
    Formalin-fixed, paraffin-embedded Rat Pancreas stained with Spectrin beta III Monoclonal Antibody (SPTBN2/1247).
  • IHC-P - Anti-Spectrin beta III (SPTBN2) Antibody AH13518-20
    Formalin-fixed, paraffin-embedded Mouse Kidney stained with Spectrin beta III Monoclonal Antibody (SPTBN2/1247).
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, FC
Primary Accession O15020
Other Accession 26915
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG3
Clone Names SPTBN2/1247
Calculated MW 271325 Da
Additional Information
Gene ID 6712
Other Names Beta III spectrin; SCA5; Spectrin beta chain brain 2; Spectrin beta non-erythrocytic 2; Spectrin non-erythroid beta chain 2; Spinocerebellar ataxia 5; SPTBN2
Application Note Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (0.5-1ug/ml); ,Western Blotting (0.5-1.0ug/ml);,Immunohistology (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
PrecautionsAnti-Spectrin beta III (SPTBN2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPTBN2
Synonyms KIAA0302, SCA5
Function Probably plays an important role in neuronal membrane skeleton.
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm, cell cortex
Tissue Location Highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta
Research Areas
Citations (0)

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Background

Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II), four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin α and spectrin β are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β I (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin β III is highly homologous to both spectrin β I and spectrin β II. Spectrin β III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.

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$ 199.00
$ 429.00
Cat# AH13518-20
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