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Anti-MAML2 Antibody

Mouse Monoclonal Antibody

     
  • IHC-P - Anti-MAML2 Antibody AH13592-20
    Formalin-fixed, paraffin-embedded Human Pancreas stained with MAML2 Monoclonal Antibody (MAML2/1302).
    detail
  • IHC-P - Anti-MAML2 Antibody AH13592-20
    Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with MAML2 Monoclonal Antibody (MAML2/1302).
    detail
  • IHC-P - Anti-MAML2 Antibody AH13592-20
    Formalin-fixed, paraffin-embedded Human Bladder Carcinoma stained with MAML2 Monoclonal Antibody (MAML2/1302).
    detail
  • IHC-P - Anti-MAML2 Antibody AH13592-20
    Formalin-fixed, paraffin-embedded Human Placenta stained with MAML2 Monoclonal Antibody (MAML2/1302).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, FC
Primary Accession Q8IZL2
Other Accession 428214
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a
Clone Names MAML2/1302
Calculated MW 125197 Da
Additional Information
Gene ID 84441
Other Names Mam-2; MAML2; Mastermind-like protein 2
Application Note Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (0.5-1ug/ml); ,Western Blotting (0.5-1ug/ml); ,Immunohistology (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
PrecautionsAnti-MAML2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAML2
Synonyms KIAA1819
Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
Cellular Location Nucleus speckle. Note=Nuclear, in a punctate manner
Tissue Location Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle
Research Areas
Citations (0)
citation

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Background

MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.

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$ 219.00
$ 499.00
Cat# AH13592-20
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