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SOX2 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • IHC - SOX2 antibody - N-terminal region AI10030
    SOX2 antibody - N-terminal region (AI10030) in Human Kidney cells using Immunohistochemistry
    Human Kidney
  • IHC - SOX2 antibody - N-terminal region AI10030
    SOX2 antibody - N-terminal region (AI10030) in Human Spleen cells using Immunohistochemistry
    Human Spleen
  • IHC - SOX2 antibody - N-terminal region AI10030
    SOX2 antibody - N-terminal region (AI10030) in Xenopus laevis cornea epithellium cells using Immunohistochemistry
    Researcher:Kim Perry, University of Illinois
    Application:IHC
    Species+tissue/cell type:Xenopus laevis cornea epithellium
    Primary Antibody Dilution:1:300
    Secondary Antibody:Goat anti-rabbit -rhodamine
    Secondary Antibody Dilution:1:300
  • WB - SOX2 antibody - N-terminal region AI10030
    SOX2 antibody - N-terminal region (AI10030) in U87 cells using Western Blot
    Sample Type: Lane 1: 20 ug U87 lysate
    Primary Antibody Dilution: 1:1000
    Secondary Antibody: Anti-rabbit-HRP
    Secondary Antibody Dilution: 1:2000
    Submitted by: Ander Matheu Fernandez, Biodonostia Institute
  • WB - SOX2 antibody - N-terminal region AI10030
    SOX2 antibody - N-terminal region (AI10030) in Human OVCAR-3 cells using Western Blot
    WB Suggested Anti-SOX2 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:500
    Positive Control: OVCAR-3 cell lysate
    There is BioGPS gene expression data showing that SOX2 is expressed in OVCAR3
  • SPECIFICATION
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P48431
Other Accession P48431, NP_003097, NM_003106
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Goat, Dog, Horse, Sheep, Bovine
Predicted Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Dog, Horse, Sheep, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 34 kDa
Additional Information
Gene ID 6657
Alias Symbol ANOP3, MCOPS3, MGC2413
Other Names Transcription factor SOX-2, SOX2
Target/Specificity SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-SOX2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSOX2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX2
Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

This is a rabbit polyclonal antibody against SOX2. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).

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$ 293.00
Cat# AI10030
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