|Other Accession||Q04725, NP_003251, NM_003260|
|Reactivity||Human, Mouse, Rat, Pig, Dog, Guinea Pig, Horse, Bovine|
|Predicted||Human, Mouse, Rat, Dog, Horse, Bovine|
|Calculated MW||80 kDa|
|Alias Symbol||ESG, ESG2, FLJ41188, GRG2|
|Other Names||Transducin-like enhancer protein 2, Enhancer of split groucho-like protein 2, ESG2, TLE2|
|Target/Specificity||TLE2 belongs to the WD repeat Groucho/TLE family. It contains 6 WD repeats. TLE2 is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TLE2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TLE2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).|
|Tissue Location||In all tissues examined, mostly in heart, brain, and muscle|
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