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HDAC1 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - HDAC1 antibody - middle region AI10051
    HDAC1 antibody - middle region (AI10051) in Hum. Adult Placenta cells using Western Blot
    Host:Rabbit
    Target Name:HDAC1
    Sample Tissue:Human Adult Placenta
    Antibody Dilution: 1.0μg/ml
  • WB - HDAC1 antibody - middle region AI10051
    HDAC1 antibody - middle region (AI10051) in Hum. Fetal Heart cells using Western Blot
    Host:Rabbit
    Target Name:HDAC1
    Sample Tissue:Human Fetal Heart
    Antibody Dilution: 1.0μg/ml
  • WB - HDAC1 antibody - middle region AI10051
    HDAC1 antibody - middle region (AI10051) in Hum. Fetal Liver cells using Western Blot
    Host:Rabbit
    Target Name:HDAC1
    Sample Tissue:Human Fetal Liver
    Antibody Dilution: 1.0μg/ml
  • WB - HDAC1 antibody - middle region AI10051
    HDAC1 antibody - middle region (AI10051) in Hum. Fetal Lung cells using Western Blot
    Host:Rabbit
    Target Name:HDAC1
    Sample Tissue:Human Fetal Lung
    Antibody Dilution: 1.0μg/ml
  • IHC - HDAC1 antibody - middle region AI10051
    HDAC1 antibody (AI10051) in Human Heart cells using Immunohistochemistry
    Rabbit Anti-HDAC1 antibody
    Catalog Number: AI10051
    Paraffin Embedded Tissue: Human Heart cell
    Cellular Data: Epithelial cells of renal tubule
    Antibody Concentration: 4.0-8.0 μg/ml
    Magnification: 400X
  • WB - HDAC1 antibody - middle region AI10051
    HDAC1 antibody - middle region (AI10051) in Human Jurkat cells using Western Blot
    WB Suggested Anti-HDAC1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:2500
    Positive Control: Jurkat cell lysate
    HDAC1 is supported by BioGPS gene expression data to be expressed in Jurkat
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q13547
Other Accession Q13547, NP_004955, NM_004964
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine, Yeast
Predicted Human, Mouse, Rat, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 55 kDa
Additional Information
Gene ID 3065
Alias Symbol DKFZp686H12203, GON-10, HD1, RPD3, RPD3L1
Other Names Histone deacetylase 1, HD1, HDAC1, RPD3L1
Target/Specificity Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HDAC1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHDAC1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC1
Synonyms RPD3L1
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
Cellular Location Nucleus.
Tissue Location Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain
Research Areas
Citations (0)

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Background

This is a rabbit polyclonal antibody against HDAC1. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).

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$ 293.00
Cat# AI10051
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