|Other Accession||Q04724, NP_005068, NM_005077|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine|
|Predicted||Human, Rabbit, Pig, Chicken, Dog, Horse, Bovine|
|Calculated MW||83 kDa|
|Alias Symbol||ESG, ESG1, GRG1|
|Other Names||Transducin-like enhancer protein 1, E(Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1|
|Target/Specificity||TLE1 is a transcriptional corepressor that binds to a number of transcription factors. TLE1 inhibits NF-kappa-B-regulated gene expression and the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE1 has an unusual function as coactivator for ESRRG.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TLE1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TLE1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.|
|Cellular Location||Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components|
|Tissue Location||In all tissues examined, mostly in brain, liver and muscle|
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