|Application ||WB, IHC|
|Other Accession||Q04727, NP_008936, NM_007005|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Dog, Guinea Pig, Horse, Bovine|
|Calculated MW||84 kDa|
|Alias Symbol||BCE-1, E(spI), ESG, ESG4, GRG4, BCE1|
|Other Names||Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4, TLE4, GRG4, KIAA1261|
|Target/Specificity||TLE4 is the transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TLE4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TLE4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).|
|Tissue Location||In all tissues examined, mostly in brain, and muscle|
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This is a rabbit polyclonal antibody against TLE4. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (firstname.lastname@example.org).
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