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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   WWTR1 antibody - N-terminal region   

WWTR1 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - WWTR1 antibody - N-terminal region AI10065
    WWTR1 Antibody (AI10065) in Human HepG2 Whole Cell using Western Blot
    Host: Rabbit
    Target Name: WWTR1
    Sample Tissue: HepG2 Whole Cell lysates

    Antibody Dilution: 1.0μg/ml
  • WB - WWTR1 antibody - N-terminal region AI10065
    WWTR1 antibody - N-terminal region (AI10065) in Human HepG2 cells using Western Blot
    WB Suggested Anti-WWTR1 Antibody Titration: 0.2-1 μg/ml
    Positive Control: HepG2 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9GZV5
Other Accession Q9GZV5, NP_056287, NM_015472
Reactivity Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Bovine
Predicted Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 44 kDa
Additional Information
Gene ID 25937
Alias Symbol DKFZP586I1419, TAZ
Other Names WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, WWTR1, TAZ
Target/Specificity TAZ (transctiptional coactivator with PDZ-binding motif), also known as WW domain containing transcription regulator 1 (WWTR1), is a member of the bicoid sub-family of homeodomain-containing transcription factors. TAZ is a 14-3-3 binding protein that co-activates Runx2-dependent gene transcription while repressing PPAR-gamma-dependent gene transcription. TAZ has been reported to be a modulator of mesenchymal stem cell differentiation. TAZ may also play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-WWTR1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsWWTR1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WWTR1
Synonyms TAZ
Function Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Cellular Location Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15
Tissue Location Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue
Research Areas
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This is a rabbit polyclonal antibody against WWTR1. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (

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$ 293.00
Cat# AI10065
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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