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NPM1 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - NPM1 antibody - N-terminal region AI10110
    NPM1 antibody - N-terminal region (AI10110) in HepG2 cells using Western Blot
    Host: Rabbit
    Target Name:NPM1
    Sample Tissue:HepG2
    Lane A:Primary Antibody
    Lane B: Primary Antibody + Blocking Peptide
    Primary Antibody
    Peptide Concentration: 2.0μg/ml
    Lysate Quantity: 25ug/lane
    Concentration: 12%There is BioGPS gene expression data showing that NPM1 is expressed in HepG2
  • IHC - NPM1 antibody - N-terminal region AI10110
    NPM1 antibody - N-terminal region (AI10110) in Human Lung cells using Immunohistochemistry
    Human Lung
  • IHC - NPM1 antibody - N-terminal region AI10110
    NPM1 antibody - N-terminal region (AI10110) in human cornea cells using Immunohistochemistry
    Sample Type: human cornea (frozen)
    Blue: DAPI
    Red: NPM1
    Primary Dilution: 1:100
    Submitted by: Geraint Parfitt
    Gavin Herbert Eye Institute See Customer Feedback tab for detailed information.
  • WB - NPM1 antibody - N-terminal region AI10110
    NPM1 antibody - N-terminal region (AI10110) in Human HepG2 cells using Western Blot
    WB Suggested Anti-NPM1 Antibody Titration: 1.0μg/ml
    Positive Control: HepG2 cell lysate
    There is BioGPS gene expression data showing that NPM1 is expressed in HepG2
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06748
Other Accession P06748, NP_002511, NM_002520
Reactivity Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine
Predicted Human, Mouse, Rabbit, Guinea Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 33 kDa
Additional Information
Gene ID 4869
Alias Symbol B23, NPM
Other Names Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1, NPM
Target/Specificity NPM1 is a member of Nucleophosmin (NPM) family. NPM is a ubiquitously expressed nucleolar phosphoprotein that continuously shuttles between the nucleus and cytoplasm
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-NPM1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsNPM1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPM1
Synonyms NPM
Function Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
Cellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis
Research Areas
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This is a rabbit polyclonal antibody against NPM1. It was validated on Western Blot and immunohistochemistry by Abgent. At Abgent we manufacture rabbit polyclonal antibodies on a large scale (200-1000 products/month) of high throughput manner. Our antibodies are peptide based and protein family oriented. We usually provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (

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$ 232.00
Cat# AI10110
(40 western blots)
Availability: 2-3 days
Bulk Size
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