|Other Accession||P55196, EAW47480, NM_001040000|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine, Yeast|
|Predicted||Human, Mouse, Rat, Zebrafish, Chicken, Dog, Horse, Bovine|
|Calculated MW||74 kDa|
|Alias Symbol||RP3-470B24.4, AF-6, AF6, AFADIN, FLJ34371, RP3-431P23.3|
|Other Names||Afadin, ALL1-fused gene from chromosome 6 protein, Protein AF-6, MLLT4, AF6|
|Target/Specificity||AF6 is a Ras target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL in leukemias caused by t(6, 11) translocations.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-MLLT4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MLLT4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.|
|Cellular Location||Cell junction, adherens junction. Note=Not found at cell-matrix AJs|
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