|Other Accession||Q9H4L7, AAH17953, Q05D56|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Dog, Horse, Bovine|
|Calculated MW||39 kDa|
|Alias Symbol||DKFZp762K2015, ETL1, KIAA1122, HEL1, ADERM|
|Other Names||SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1, ATP-dependent helicase 1, hHEL1, SMARCAD1, KIAA1122|
|Target/Specificity||SMARCAD1 belongs to the SNF2/RAD54 helicase family. It contains 2 CUE domains, 1 helicase ATP-binding domain, and 1 helicase C-terminal domain. It is a probable ATP-dependent DNA helicase.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SMARCAD1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SMARCAD1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing.|
|Cellular Location||Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double- strand breaks (DSBs) sites of DNA damage|
|Tissue Location||Isoform 1 is expressed ubiquitously. Isoform 3 is expressed mainly in skin, fibroblasts, keratinocytes and esophagus.|
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