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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TNFRSF10B Antibody   

TNFRSF10B Antibody

Mouse Antibody

     
  • WB - TNFRSF10B Antibody AI10155
    WB Suggested Anti-TNFRSF1B Antibody
    Titration: 1 μg/ml
    Positive Control: Placenta
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O14763
Other Accession NM_003842, NP_671716
Reactivity Human
Host Mouse
Isotype Mouse IgM,k
Clone Names 11G7
Calculated MW 42 KDa
Additional Information
Gene ID 8795
Alias Symbol DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5
Other Names Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2, CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100ul of distilled water. Final anti-TNFRSF10B antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -200°C. Avoid repeat freeze-thaw cycles.
PrecautionsTNFRSF10B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF10B
Synonyms DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain
Research Areas
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$ 253.00
Cat# AI10155
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