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TNFRSF10B Antibody
Mouse Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O14763 |
| Other Accession | NM_003842, NP_671716 |
| Reactivity | Human |
| Host | Mouse |
| Isotype | Mouse IgM,k |
| Clone Names | 11G7 |
| Calculated MW | 42 KDa |
| Gene ID | 8795 |
|---|---|
| Alias Symbol | DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5 |
| Other Names | Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2, CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100ul of distilled water. Final anti-TNFRSF10B antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -200°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TNFRSF10B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFRSF10B |
|---|---|
| Synonyms | DR5, KILLER, TRAILR2, TRICK2, ZTNFR9 |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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