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>   home   >   Products   >   Primary Antibodies   >   Ccl20 antibody - C-terminal region   

Ccl20 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Ccl20 antibody - C-terminal region AI10192
    WB Suggested Anti-Ccl2 Antibody Titration: .2-1 μg/ml
    ELISA Titer: 1:625
    Positive Control: Rat Heart
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P97884
Other Accession NM_019233, NP_062106
Reactivity Human, Mouse, Rat, Pig, Horse, Dog
Predicted Human, Mouse, Rat, Pig, Chicken, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 11kDa
Additional Information
Gene ID 29538
Alias Symbol ST38, Scya20, Ccl20
Other Names C-C motif chemokine 20, Beta-chemokine exodus-1, CC chemokine LARC, CC chemokine ST38, Liver and activation-regulated chemokine, Macrophage inflammatory protein 3 alpha, MIP-3-alpha, Small-inducible cytokine A20, Ccl20, Scya20, St38
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Ccl20 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCcl20 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ccl20
Synonyms Scya20, St38
Function Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T- cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.
Cellular Location Secreted {ECO:0000250|UniProtKB:P78556}.
Tissue Location Low levels in thymus and lung.
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$ 293.00
Cat# AI10192
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