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ZBTB48 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P10074 |
| Other Accession | NM_005341, NP_005332 |
| Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Chicken, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37kDa |
| Gene ID | 3104 |
|---|---|
| Alias Symbol | HKR3, pp9964, ZNF855 |
| Other Names | Zinc finger and BTB domain-containing protein 48, Krueppel-related zinc finger protein 3, Protein HKR3, Zinc finger protein 855, ZBTB48, HKR3, ZNF855 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ZBTB48 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ZBTB48 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZBTB48 (HGNC:4930) |
|---|---|
| Function | Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). |
| Cellular Location | Nucleus. Chromosome, telomere Note=Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411). According to another report, binds telomeres regardless of their length (PubMed:28500257) |
| Tissue Location | Detected in adrenal gland and neuroblastoma. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Maris,J.M., (1996) Genomics 35 (2), 289-298Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Kim, K. et al. Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Mol. Cancer Ther. 11, 1852-62 (2012). WB, Human, Bovine, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse22752225
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