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ZNF445 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P59923 |
| Other Accession | NM_181489, NP_852466 |
| Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Dog |
| Predicted | Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 119kDa |
| Gene ID | 353274 |
|---|---|
| Alias Symbol | MGC126535, ZKSCAN15, ZNF168 |
| Other Names | Zinc finger protein 445, Zinc finger protein 168, Zinc finger protein with KRAB and SCAN domains 15, ZNF445, ZKSCAN15, ZNF168 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ZNF445 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ZNF445 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF445 (HGNC:21018) |
|---|---|
| Function | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). |
| Cellular Location | Nucleus. Note=Binds various differentially methylated regions (DMR) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Luo,K., Gene 367, 89-100 (2006)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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