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>   home   >   Products   >   Primary Antibodies   >   SKIIP antibody - N-terminal region   

SKIIP antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - SKIIP antibody - N-terminal region AI10339
    WB Suggested Anti-SKIIP Antibody Titration: .2-1 μg/ml
    Positive Control: Jurkat cell lysate

    SNW1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells

  • IHC - SKIIP antibody - N-terminal region AI10339
    Human Intestine
  • IHC - SKIIP antibody - N-terminal region AI10339
    Rabbit Anti-SKIIP antibody

    Catalog Number:

    Paraffin Embedded Tissue:
    Human Lung cell

    Cellular Data:
    Epithelial cells of renal tubule

    Antibody Concentration:
    4.-8. μg/ml

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13573
Other Accession NM_012245, NP_036377
Reactivity Human, Mouse, Rat, Pig, Horse, Yeast, Bovine, Dog
Predicted Human, Mouse, Rat, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 61kDa
Additional Information
Gene ID 22938
Alias Symbol Bx42, SKIP, Prp45, SKIIP, PRPF45, NCOA-62
Other Names SNW domain-containing protein 1, Nuclear protein SkiP, Nuclear receptor coactivator NCoA-62, Ski-interacting protein, SNW1, SKIIP, SKIP
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-SKIIP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSKIIP antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNW1
Synonyms SKIIP, SKIP
Function Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Cellular Location Nucleus.
Citations (0)

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Figueroa,J.D., et al., (2004) Eur.Res.Commun.319(4),1105-1109Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 293.00
Cat# AI10339
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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