|Reactivity||Human, Mouse, Rat, Zebrafish, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Zebrafish, Pig, Bovine, Guinea Pig, Dog|
|Other Names||Mothers against decapentaplegic homolog 6, MAD homolog 6, Mothers against DPP homolog 6, Mad homolog 7, SMAD family member 6, SMAD 6, Smad6, Smad6, Madh6, Madh7, Msmad6|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-Smad6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Smad6 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Madh6, Madh7, Msmad6|
|Function||Binds to regulatory elements in target promoter regions (By similarity). May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (By similarity). Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.|
|Tissue Location||Ubiquitous in various organs, with higher levels in lung|
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