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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > Smad6 Antibody - C-terminal region
Smad6 Antibody - C-terminal region
Rabbit Polyclonal Antibody
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O35182 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Pig, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Zebrafish, Pig, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54kDa |
| Gene ID | 17130 |
|---|---|
| Other Names | Mothers against decapentaplegic homolog 6, MAD homolog 6, Mothers against DPP homolog 6, Mad homolog 7, SMAD family member 6, SMAD 6, Smad6, Smad6, Madh6, Madh7, Msmad6 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-Smad6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Smad6 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Smad6 |
|---|---|
| Synonyms | Madh6, Madh7, Msmad6 |
| Function | Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (By similarity). Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous in various organs, with higher levels in lung |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI10402
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