|Other Accession||NM_006186, NP_006177|
|Reactivity||Human, Mouse, Rat, Zebrafish, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Zebrafish, Pig, Chicken, Bovine, Dog|
|Alias Symbol||HZF-3, NOT, NURR1, RNR1, TINUR|
|Other Names||Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor, NR4A2, NOT, NURR1, TINUR|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-NR4A2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NR4A2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NOT, NURR1, TINUR|
|Function||Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization|
|Tissue Location||Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue|
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Provided below are standard protocols that you may find useful for product applications.
Holla,V.R., (2006) J. Biol. Chem. 281 (5), 2676-2682 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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