|Application ||WB, IHC|
|Other Accession||NM_006663, NP_006654|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Bovine, Guinea Pig, Dog|
|Alias Symbol||IASPP, NKIP1, RAI, iASPP gene, RAI4|
|Other Names||RelA-associated inhibitor, Inhibitor of ASPP protein, Protein iASPP, NFkB-interacting protein 1, PPP1R13B-like protein, PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PPP1R13L antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PPP1R13L antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IASPP, NKIP1, PPP1R13BL, RAI|
|Function||Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.|
|Tissue Location||Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte|
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Provided below are standard protocols that you may find useful for product applications.
Tomoda,K., (2008) Cancer Sci. 99 (3), 615-622 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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