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Fa2h antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
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Application 
| WB |
|---|---|
| Primary Accession | Q5MPP0 |
| Other Accession | NM_178086, NP_835187 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Zebrafish, Pig, Chicken, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43kDa |
| Gene ID | 338521 |
|---|---|
| Alias Symbol | FAAH, Faxdc1, G630055L08Rik |
| Other Names | Fatty acid 2-hydroxylase, 1.-.-.-, Fatty acid alpha-hydroxylase, Fa2h, Faah |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Fa2h antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Fa2h antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FA2H |
|---|---|
| Function | Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15658937, PubMed:16998236, PubMed:22517924). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (PubMed:15658937, PubMed:18815260). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (PubMed:21628453). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (PubMed:22517924). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in brain (at protein level) (PubMed:16998236). Detected in cerebellum and forebrain (PubMed:18815260, PubMed:15658937). Expression in the white matter is mainly restricted in oligodendrocytes (PubMed:15658937). Expressed in stomach, kidney, skin and testis (PubMed:15658937). Expressed in sebaceous gland (PubMed:21628453). |
Research Areas
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$ 389.00
Cat# AI10466
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