|Other Accession||NM_023764, NP_076253|
|Reactivity||Human, Mouse, Rat, Zebrafish, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Zebrafish, Pig, Chicken, Guinea Pig, Dog|
|Alias Symbol||4930403G24Rik, 4931428G15Rik|
|Other Names||Toll-interacting protein, Tollip|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Tollip antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Tollip antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).|
|Tissue Location||Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney, thymus, pancreas and testis|
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