|Application ||WB, IF|
|Other Accession||NM_201441, NP_958849|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Pig, Chicken, Bovine, Guinea Pig, Dog|
|Alias Symbol||EFTR-2, MGC9014, RTEF1, TCF13L1, TEF-3, TEFR-1, hRTEF-1B, TEF3|
|Other Names||Transcriptional enhancer factor TEF-3, TEA domain family member 4, TEAD-4, Transcription factor 13-like 1, Transcription factor RTEF-1, TEAD4, RTEF1, TCF13L1, TEF3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TEAD4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TEAD4 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||RTEF1, TCF13L1, TEF3|
|Function||Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.|
|Tissue Location||Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart|
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Provided below are standard protocols that you may find useful for product applications.
Appukuttan,B., (2007) Invest. Ophthalmol. Vis. Sci. 48 (8), 3775-3782 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Chan, S. W. et al. TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J. Biol. Chem. 284, 14347-58 (2009). WB, Pig, Human, Bovine, Dog, Horse, Rabbit, Guinea pig, Mouse, Rat19324876
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