|Other Accession||NM_011567, NP_035697|
|Reactivity||Human, Mouse, Rat, Zebrafish, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Pig, Chicken, Bovine, Guinea Pig|
|Alias Symbol||ETFR-2, Etfr2, FR-19, TEAD-4, TEF-3, Tcf13r1, Tef3, Tefr, Tefr1, Tefr1a|
|Other Names||Transcriptional enhancer factor TEF-3, ETF-related factor 2, ETFR-2, TEA domain family member 4, TEAD-4, TEF-1-related factor 1, TEF-1-related factor FR-19, RTEF-1, Tead4, Tcf13r1, Tef3, Tefr1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Tead4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Tead4 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Tcf13r1, Tef3, Tefr1|
|Function||Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle.|
|Tissue Location||Preferentially expressed in lung and in skeletal muscle|
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