|Other Accession||NM_000052, NP_000043|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Bovine, Guinea Pig, Dog|
|Alias Symbol||MK, MNK, DSMAX, SMAX3|
|Other Names||Copper-transporting ATPase 1, 220.127.116.11, Copper pump 1, Menkes disease-associated protein, ATP7A, MC1, MNK|
|Target/Specificity||This antibody is will react to isoforms 1-5.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ATP7A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ATP7A antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Cycles constitutively between the trans-Golgi network (TGN) and the plasma membrane (PubMed:9147644) Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels Isoform 5: Endoplasmic reticulum|
|Tissue Location||Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Zhang,L.P., (2008) Chin. Med. J. 121 (2), 175-177 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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