|Application ||WB, IHC|
|Other Accession||NM_008970, NP_032996|
|Reactivity||Human, Mouse, Rat, Goat, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Pig, Chicken, Guinea Pig|
|Alias Symbol||PTH-like, Pthrp|
|Other Names||Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP, Osteostatin, Pthlh, Pthrp|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Pthlh antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Pthlh antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.|
|Cellular Location||Cytoplasm. Nucleus. Secreted|
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