|Other Accession||NM_032559, NP_115948|
|Reactivity||Human, Mouse, Rat, Zebrafish, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog|
|Other Names||Kinesin-like protein KIF2B, KIF2B|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-KIF2B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KIF2B antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Note=Association with kinetochore is transient|
|Tissue Location||Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Manning,A.L., (2007) Mol. Biol. Cell 18 (8), 2970-2979 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Shrestha, R. L. & Draviam, V. M. Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr. Biol. 23, 1514-26 (2013). WB, Human, Dog, Rabbit, Guinea pig, Mouse, Bovine, Horse, Rat, Zebrafish23891108
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