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Trim35 Antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8C006 |
| Other Accession | NM_029979, NP_084255 |
| Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 55kDa |
| Gene ID | 66854 |
|---|---|
| Alias Symbol | 0710005M05Rik, A430106H13Rik, AW046487, HLS5, Mair, NC8, mKIAA1098 |
| Other Names | Tripartite motif-containing protein 35, Hemopoietic lineage switch protein 5, Macrophage-derived apoptosis-inducing RBCC protein, Protein MAIR, Protein Nc8, Trim35, Hls5, Kiaa1098, Mair |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-Trim35 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Trim35 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Trim35 |
|---|---|
| Synonyms | Hls5, Kiaa1098, Mair |
| Function | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response (By similarity) (PubMed:32562145). Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Note=Found predominantly in cytoplasm with a granular distribution Found in punctuate nuclear bodies in transfected COS and HeLa cells |
| Tissue Location | Widely expressed. Highly expressed in brain, heart, kidney, spleen, skeletal muscle, lung and thymus. Lower expression found in stomach, large intestine and bone marrow |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI10646
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