C21ORF18 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9NVD3 |
Other Accession | NM_017438, NP_059134 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog |
Predicted | Human, Mouse, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 50kDa |
Gene ID | 54093 |
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Alias Symbol | C21orf18, C21orf27 |
Other Names | SET domain-containing protein 4, 2.1.1.-, SETD4, C21orf18, C21orf27 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-C21ORF18 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | C21ORF18 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SETD4 {ECO:0000303|PubMed:24738023, ECO:0000312|HGNC:HGNC:1258} |
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Function | Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31308046). Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro- inflammatory cytokines IL6 and TNF-alpha (By similarity). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). |
Cellular Location | Cytoplasm, cytosol. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
References
Reymond,A., et al., (2001) Genomics 78 (1-2), 46-54Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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