|Other Accession||NM_025221, NP_079497|
|Reactivity||Human, Mouse, Rat, Rabbit, Bovine, Dog|
|Predicted||Human, Mouse, Rabbit, Dog|
|Alias Symbol||CALP, KCHIP4|
|Other Names||Kv channel-interacting protein 4, KChIP4, A-type potassium channel modulatory protein 4, Calsenilin-like protein, Potassium channel-interacting protein 4, KCNIP4, CALP, KCHIP4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-KCNIP4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KCNIP4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.|
|Cellular Location||Cell membrane; Peripheral membrane protein Cytoplasm|
|Tissue Location||Predominantly expressed in brain.|
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