|Application ||WB, IHC|
|Other Accession||NM_033222, NP_150091|
|Reactivity||Human, Mouse, Rat, Rabbit, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Sheep, Horse, Bovine, Dog|
|Alias Symbol||p52, p75, PAIP, DFS70, LEDGF, PSIP2|
|Other Names||PC4 and SFRS1-interacting protein, CLL-associated antigen KW-7, Dense fine speckles 70 kDa protein, DFS 70, Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52, PSIP1, DFS70, LEDGF, PSIP2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-PSIP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PSIP1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DFS70, LEDGF, PSIP2|
|Function||Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.|
|Cellular Location||Nucleus. Note=Remains chromatin-associated throughout the cell cycle|
|Tissue Location||Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions|
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Provided below are standard protocols that you may find useful for product applications.
Vandegraaff,N., et al., (2006) Virology 346 (2), 415-426Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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