|Other Accession||NM_001110860, NP_001104330|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Bovine, Dog|
|Other Names||cAMP-responsive element modulator, Crem|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Crem antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Crem Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Delta is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform Tau (activator) to CRE is increased by CREB3L4. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (By similarity).|
|Tissue Location||Isoform Tau is expressed in testis germ cells. CREM-theta1- and CREM-theta2-containing isoforms are expressed in testis.|
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