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HSF2BP antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - HSF2BP antibody - N-terminal region AI10742

    WB Suggested Anti-HSF2BP Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:1562500
    Positive Control: Human Lung
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O75031
Other Accession NM_007031, NP_008962
Reactivity Human, Mouse, Rat, Rabbit, Pig, Bovine, Dog
Predicted Human, Mouse, Rabbit, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 38kDa
Additional Information
Gene ID 11077
Other Names Heat shock factor 2-binding protein, HSF2BP
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HSF2BP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHSF2BP antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSF2BP (HGNC:5226)
Function Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed:31242413). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis (PubMed:9651507).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9D4G2}. Chromosome. Note=Localizes on double- strand breaks (DSBs) in mitotic and meiotic chromosomes
Tissue Location Testis specific. Overexpressed in some tumors (PubMed:31242413).
Research Areas
Citations (0)
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References

Hu,Y.H., (er) BMC Genomics 7, 155 (2006)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 389.00
Cat# AI10742
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