|Predicted||Human, Rat, Rabbit, Horse|
|Alias Symbol||TRIM40, RNF35,|
|Other Names||Tripartite motif-containing protein 40, Probable E3 NEDD8-protein ligase, RING finger protein 35, TRIM40, RNF35|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-TRI40 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TRI40 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.|
|Tissue Location||Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.|
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