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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > Glra3 antibody - middle region
Glra3 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q91XP5 |
| Other Accession | NM_080438, NP_536686 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56kDa |
| Gene ID | 110304 |
|---|---|
| Other Names | Glycine receptor subunit alpha-3, Glra3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Glra3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Glra3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Glra3 |
|---|---|
| Function | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:15131310, PubMed:20978350). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:15131310). Contributes to increased pain perception in response to increased prostaglandin E2 levels (PubMed:15131310). Plays a role in the regulation of breathing rhythm, especially of the duration of the postinspiratory phase (PubMed:20978350). Plays a role in cellular responses to ethanol (By similarity). |
| Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Synapse. Perikaryon. Cell projection, dendrite {ECO:0000250|UniProtKB:P24524}. Cell membrane; Multi-pass membrane protein. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes |
| Tissue Location | Detected in brainstem, also in neurons that control rhythmic breathing (PubMed:20978350). Detected in superficial laminae of the dorsal horn of the thoracic spinal cord (PubMed:15131310) Detected in dentate gyrus in hippocampus, especially in stratum granulare (PubMed:19723286). Detected in the inner plexiform layer in the retina (at protein level) (PubMed:12975813). Detected in midbrain, thalamus, brain cortex, hippocampus, and at lower levels in cerebellum (PubMed:19723286). |
Research Areas
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Application Protocols
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$ 389.00
Cat# AI10781
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