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Glra3 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - Glra3 antibody - middle region AI10781

    WB Suggested Anti-Glra3 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Small Intestine
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q91XP5
Other Accession NM_080438, NP_536686
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 56kDa
Additional Information
Gene ID 110304
Other Names Glycine receptor subunit alpha-3, Glra3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Glra3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGlra3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Glra3
Function Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:15131310, PubMed:20978350). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:15131310). Contributes to increased pain perception in response to increased prostaglandin E2 levels (PubMed:15131310). Plays a role in the regulation of breathing rhythm, especially of the duration of the postinspiratory phase (PubMed:20978350). Plays a role in cellular responses to ethanol (By similarity).
Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi- pass membrane protein. Cell junction, synapse. Perikaryon. Cell projection, dendrite {ECO:0000250|UniProtKB:P24524}. Cell membrane; Multi-pass membrane protein. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes
Tissue Location Detected in brainstem, also in neurons that control rhythmic breathing (PubMed:20978350). Detected in superficial laminae of the dorsal horn of the thoracic spinal cord (PubMed:15131310). Detected in dentate gyrus in hippocampus, especially in stratum granulare (PubMed:19723286). Detected in the inner plexiform layer in the retina (at protein level) (PubMed:12975813). Detected in midbrain, thalamus, brain cortex, hippocampus, and at lower levels in cerebellum (PubMed:19723286)
Research Areas
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$ 293.00
Cat# AI10781
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