|Application ||WB, IHC|
|Other Accession||NM_021614, NP_067627|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Yeast, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Dog|
|Alias Symbol||SK2, hSK2, SKCA2, KCa2.2|
|Other Names||Small conductance calcium-activated potassium channel protein 2, SK2, SKCa 2, SKCa2, KCa2.2, KCNN2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-KCNN2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KCNN2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in atrial myocytes (at protein level). Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Feranchak,A.P., et al., (2004) Gastroenterology 127 (3), 903-913Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Chakroborty, S. et al. Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer’s disease mice. J. Neurosci. 32, 8341-53 (2012). WB, IHC, Human, Yeast, Zebrafish, Mouse, Rat, Bovine, Dog, Pig, H, Rabbit, Guinea pig22699914
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